Mycobacterial ATP synthase with bedaquiline
Mycobacterial ATP synthase with bedaquiline

CryoEM map of the mycobacterial ATP synthase with the TB drug bedaquiline

Brain V-ATPase
Brain V-ATPase

CryoEM map of V-ATPase from the mammalian brain

ATP synthase
ATP synthase

'Mosaic model' of the intact mitochondrial ATP synthase

Mycobacterial ATP synthase with bedaquiline
Mycobacterial ATP synthase with bedaquiline

CryoEM map of the mycobacterial ATP synthase with the TB drug bedaquiline

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Who we are

Our group, consisting of biophysicists and biochemists, studies the structure and function of macromolecular assemblies using electron cryomicroscopy (cryo-EM), image analysis, biochemistry and molecular genetics. We also develop the tools of cryo-EM so that we can answer questions that are not amenable to the techniques that currently exist.