Mycobacterial ATP synthase with bedaquiline
Mycobacterial ATP synthase with bedaquiline

CryoEM map of the mycobacterial ATP synthase with the TB drug bedaquiline

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Brain V-ATPase
Brain V-ATPase

CryoEM map of V-ATPase from the mammalian brain

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ATP synthase
ATP synthase

'Mosaic model' of the intact mitochondrial ATP synthase

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Mycobacterial ATP synthase with bedaquiline
Mycobacterial ATP synthase with bedaquiline

CryoEM map of the mycobacterial ATP synthase with the TB drug bedaquiline

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Who we are

Our group, consisting of biophysicists and biochemists, studies the structure and function of macromolecular assemblies using electron cryomicroscopy (cryo-EM), image analysis, biochemistry and molecular genetics. We also develop the tools of cryo-EM so that we can answer questions that are not amenable to the techniques that currently exist.