Mycobacterial ATP synthase with bedaquiline
CryoEM map of the mycobacterial ATP synthase with the TB drug bedaquiline
Brain V-ATPase
CryoEM map of V-ATPase from the mammalian brain
ATP synthase
'Mosaic model' of the intact mitochondrial ATP synthase
Mycobacterial ATP synthase with bedaquiline
CryoEM map of the mycobacterial ATP synthase with the TB drug bedaquiline
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Who we are
Our group, consisting of biophysicists and biochemists, studies the structure and function of macromolecular assemblies using electron cryomicroscopy (cryo-EM), image analysis, biochemistry and molecular genetics. We also develop the tools of cryo-EM so that we can answer questions that are not amenable to the techniques that currently exist.